OPTIMETgen is a genetic panel containing markers called “single nucleotide polymorphisms” (SNPs) related to methylation or detoxification. Based on the results, personalized recommendations are provided to optimize metabolism by balancing methylation and detoxification. This can help counterbalance the expression of the genes tested, for example on the metabolism of neurotransmitters. These recommendations are also beneficial in the prevention of age and aging-related diseases. SNP = single nucleotide polymorphism, rs number: The rs number is an access number used by researchers and databases to designate specific SNPs. This means “Reference SNP cluster ID” (–): absence of variation, (-+): presence of a variant allele (heterozygous genotype), (++): presence of two variant alleles, yellow: genotype associated with the normal susceptibility of the reference population, green: genotype associated with reduced susceptibility to reference population, red: genotype associated with increased susceptibility compared to reference population.
The report provides a comprehensive list of supplementation recommendations such as micronutrients and vitamins.
Assessment of the transsulfuration pathway, cycles of urea, tetrahydrobiopterin (BH4), folate and methionine. CBS inducers such as TNF-alpha and the underlying causes of excessive inflammatory reactions (e.g., viral or bacterial infection) should be avoided, if possible. Elimination of heavy metals if present in excess.
Decreased COMT activity: Reduced inactivation of catecholamines (dopamine, adrenaline, norepinephrine).
MTHFR rs1801133: MTHFR activity decreased. Production of 5-methyltetrahydrofolate (5-MTHF) reduced. The homocysteine level can be increased.
MTHFR rs1801131: The SAM regulatory region of MTHFR is affected. Reduction of BH4 formation from BH2. Increased dopamine, norepinephrine and epinephrine.
Enzymatic activity increased Increased need for vitamin B12
GSTM1, GSTT1, GSTP1:
The GSTM1, GSTT1 and GSTP1 isoenzymes variants assess the natural body heavy metal chelation capacity, i.e.detoxification capacity.
Lipid metabolism: high triglycerides, decreased LDL cholesterol. Risk of cardiovascular disease: decreased. Heavy Metal Chelation Capabilities: Most Optimal Versus All Other Genotypes of the APOE Gene.
The genotypes “GG” is to be considered as “secretor”. Predisposition to a decreased plasma vitamin B12 level compared to “non-secretory” individuals. No predisposition for a natural resistance to norovirus, rotavirus or Helicobacter pylori infections.
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