Blood test for Prostaglandin E2 (PGE2) (Marker of inflammation)
- PGE2 is a compound derived from membrane phospholipids.
- PGE2 is also a key mediator of immunopathology in chronic infections and cancer.
- PGE2 enhances its own production but suppresses acute inflammatory mediators, resulting in its predominance at late/chronic stages of immunity.
- PGE2 selectively suppresses effector functions of macrophages and neutrophils and the Th1-, CTL-, and NK cell-mediated type 1 immunity, but it promotes Th2, Th17, and regulatory T cell responses.
- PGE2 modulates chemokine production, inhibiting the attraction of proinflammatory cells while enhancing local accumulation of regulatory T cells and myeloid-derived suppressor cells.
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